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ActivIoss® 0.5 cc — 45S5 Bioactive Glass Synthetic Ceramic Graft for Bone Regeneration
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  • ActivIoss® 0.5 cc — 45S5 Bioactive Glass Synthetic Ceramic Graft for Bone Regeneration

ActivIoss® 0.5 cc — 45S5 Bioactive Glass Synthetic Ceramic Graft for Bone Regeneration

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ActivIoss® is a synthetic ceramic biomaterial composed of 45S5 bioactive glass (silicon, sodium, phosphorus, and calcium oxides). Acting as an osteostimulative agent, it triggers the body to generate new native bone tissue while being gradually replaced by host tissue. The primary synthetic choice when allografts or xenografts cannot be used. Predictable absorption in 6 months.

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Advanced Synthetic Bioactive Ceramic Technology for Targeted Osteostimulation

ActivIoss® is a next-generation synthetic solution engineered for bone regeneration and structural augmentation in dental and oral surgery. Formulated from pure 45S5 bioactive glass ($SiO_2$, $Na_2O$, $CaO$, $P_2O_5$), this biomaterial delivers both a physical scaffold and a active biological response termed osteostimulation.

Upon exposure to physiological fluids, ActivIoss® rapidly precipitates a calcium phosphate apatite layer that signals osteoprogenitor cells and upregulates genes responsible for new bone deposition. Its 100% synthetic origin ensures absolute biological safety with zero risk of cross-contamination or immunogenic reactions. It resorbs naturally over a 6-month window, seamlessly giving way to mature, vascularized host bone.

Key Features

  • 45S5 Bioactive Glass Composition: Precise inorganic formulation containing silica, sodium, calcium, and phosphorus oxides.

  • Osteostimulative Properties: Chemically signals osteoblasts to accelerate native bone synthesis and matrix mineralization.

  • 100% Synthetic & Biosafe: Premier alternative when human allografts or animal xenografts are contraindicated or restricted.

  • Predictable Resorption Profile (6 Months): Absorbs at a rate synchronized with natural host tissue remodeling.

  • Crestal Ridge Protection: Prevents post-extraction collapse and preserves alveolar volume.

Clinical Indications

  • Peri-Implant Surgery: Fills osseous defects around implants to ensure predictable osseointegration.

  • Sinus Floor Augmentation: Elevates the sinus membrane to gain vertical bone height.

  • Horizontal Ridge Augmentation: Restores deficient ridge width in localized atrophic areas.

  • Socket & Crest Preservation: Prevents crestal bone resorption following tooth extractions.

Technical Specifications

  • Material: Synthetic (Ceramic).

  • Composition: 45S5 Bioactive Glass ($SiO_2$, $Na_2O$, $CaO$, $P_2O_5$).

  • Biological Mechanism: Osteostimulative & Osteoconductive.

  • Resorption Rate: 6 months.

  • Applications: Implantology, Periodontics, and Oral & Maxillofacial Surgery.

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